Raphael (Rafi) received his Ph.D. and M.Sc. in Life Sciences and Chemistry from the Weizmann Institute of Science in Rehovot, Israel; and his B.Sc. in Chemistry and Physics from the Hebrew University in Jerusalem. While completing postdoctoral training and research at the Harvard Medical School in Boston, in the Departments of Biological Chemistry and Neurobiology, Rafi received the Hereditary Disease Foundation Fellowship in 1982-83 and the Chaim Weizmann Postdoctoral Fellowship in 1980-82.

From 1999 to June 2009, Rafi held the position of President and CEO of Hadasit Ltd., the technology transfer company of the Hadassah Medical Organization in Jerusalem. Rafi serves as Chair of Hadasit BioHolding Ltd., a publicly traded company on the Tel Aviv Stock Exchange (TASE) since 2005.